FMO3 anticorps (C-Term)

N° du produit ABIN3043830

Cet anticorps anti-FMO3 est un anticorps Lapin Polyclonal détectant FMO3 dans WB. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour FMO3 anticorps (C-Term) (ABIN3043830)

Antigène: FMO3 (Flavin Containing Monooxygenase 3 (FMO3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FMO3 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-FMO3 anticorps

Épitope: AA 404-433, C-Term

Fonction: Anti-FMO3 Antibody Picoband®

Séquence: DMMNDINEKM EKKRKWFGKS ETIQTDYIVY

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-FMO3 Antibody Picoband® (ABIN3043830). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human FMO3, different from the related mouse sequence by eight amino acids, and from the related rat sequence by six amino acids.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Akerman, B. R., Chow, L., Forrest, S., Youil, R., Cashman, J., Treacy, E. P. Mutations in the flavin-containing monoxygenase (sic) form 3 (FMO3) gene cause trimethylaminuria, fish odour syndrome. (Abstract) Am. J. Hum. Genet. 61 (suppl.): A53 only, 1997. 2. Cashman, J. R., Zhang, J. Interindividual differences of human flavin-containing monooxygenase 3: genetic polymorphisms and functional variation. Drug Metab. Dispos. 30: 1043-1052, 2002. 3. Dolphin, C. T., Janmohamed, A., Smith, R. L., Shephard, E. A., Phillips, I. R. Missense mutation in flavin-containing mono-oxygenase 3 gene, FMO3, underlies fish-odour syndrome. Nature Genet. 17: 491-494, 1997.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur FMO3

Antigène: FMO3 (Flavin Containing Monooxygenase 3 (FMO3))

Autre désignation: FMO3

Sujet:

Synonyms: Dimethylaniline monooxygenase [N-oxide-forming] 3,1.14.13.8,Dimethylaniline oxidase 3,FMO II,FMO form 2,Hepatic flavin-containing monooxygenase 3,FMO 3,Trimethylamine monooxygenase,1.14.13.148,FMO3,

Tissue Specificity: Liver.

Background: FMO3 (Flavin-containing Monooxygenase 3) is an enzyme that in humans is encoded by the FMO3 gene. The mammalian flavin-containing monooxygenases (FMO) represent a multigene family whose gene products are localized in the endoplasmic reticulum of many tissues. The FMO3 gene contains 1 noncoding and 8 coding exons. And the FMO3 gene is mapped on 1q24.3. Using quantitative RNase protection assays, FMO3 is present in low abundance in fetal liver and lung and in adult kidney and lung, and in much greater abundance in adult liver. By Western blot analysis of human liver microsomal samples ranging from 8 weeks gestation to 18 years of age, FMO1 is the major fetal isoform and FMO3 is the major adult isoform. FMO3 was expressed at intermediate levels until 11 years of age when a gender-independent increase in FMO3 expression was observed during puberty. Sufferers of trimethylaminuria may display a reduced ability to metabolize substrates for FMO3 such as nicotine. FMO3 metabolizes a number of drugs, including amphetamine, clozapine, deprenyl, metamphetamine, tamoxifen, ethionamide, thiacetazone, and sulindac sulfide.

Sequence Similarities: Belongs to the FMO family.

Poids moléculaire: 60 kDa

ID gène: 2328

UniProt: P31513